Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. 100% FRUITING BODIES & EXTRACTS: Superior Absorption Power Using Highly Concentrated Extracts and 100% Fruiting Bodies. Avoid repeating rimegepant dose within 48 hr if coadministered with a moderate CYP3A4 inhibitor.Serious - Use Alternative (1)verapamil will increase the level or effect of rimegepant by P-glycoprotein (MDR1) efflux transporter. verapamil will increase the level or effect of rimegepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. choline magnesium trisalicylate, perindopril. verapamil will increase the level or effect of ritonavir by P-glycoprotein (MDR1) efflux transporter. Mechanism: pharmacodynamic synergism. indomethacin, perindopril. Modify Therapy/Monitor Closely. atenolol and verapamil both increase anti-hypertensive channel blocking. Avoid or Use Alternate Drug. Minor/Significance Unknown. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (2)darifenacin will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Additive hypotensive effects. Avoid or Use Alternate Drug. perindopril, azathioprine. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Minor/Significance Unknown.quinine will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. perindopril, terazosin. Avoid or Use Alternate Drug. NSAIDs decrease prostaglandin synthesis. Avoid or Use Alternate Drug. Monitor for adverse effects if lefamulin is coadministered with moderate CYP3A inhibitors. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Stonehenge Health strives to maximize each formula's effectiveness, perfecting each dose with the highest potency and purity of ingredients. Serious - Use Alternative (1)verapamil will increase the level or effect of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. levodopa increases effects of verapamil by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. carvedilol and verapamil both increase anti-hypertensive channel blocking. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Minor/Significance Unknown. Minor/Significance Unknown. diclofenac, perindopril. Consider decreasing dosage of antihypertensive agent. Use Caution/Monitor. Ca Channel Blockers interfere w/Ach release from prejunctional axon. Monitor Closely (1)verapamil will increase the level or effect of ixabepilone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. perindopril, furosemide. Controlled studies in pregnant women show no evidence of fetal risk. Monitor Closely (2)hydralazine, serdexmethylphenidate/dexmethylphenidate. Use Caution/Monitor. Apalutamide weakly induces OATP1B1 and may decrease systemic exposure of drugs that are OATP1B1 substrates. verapamil increases effects of rocuronium by pharmacodynamic synergism. verapamil will increase the level or effect of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)naproxen, perindopril. The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure, paclitaxel protein bound will increase the level or effect of valsartan by Other (see comment). Avoid or Use Alternate Drug. Make sure all your doctors know which medicines you are using. Minor/Significance Unknown. Use Caution/Monitor. No adverse effects reported in research studies. Consult your doctor before breast-feeding. valsartan and salsalate both increase serum potassium. Higher intakes of beta-glucan (and fiber in general) may help to reduce cholesterol, manage blood sugar levels in people with diabetes, and possibly lower blood pressure. Consider reducing the dose of verapamil or withdrawing one of the agents.Minor (1)verapamil will increase the level or effect of itraconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure. Monitor Closely (2)verapamil increases levels of lurasidone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)verapamil will increase the level or effect of duloxetine by affecting hepatic enzyme CYP1A2 metabolism. Comment: OATP1B1 inhibitors may increase risk of myopathy. View the formulary and any restrictions for each plan. Eur J Nutr. Modify Therapy/Monitor Closely.Serious - Use Alternative (1)verapamil, atenolol. Half-life: 1.5-3 hr (perindopril);3-10 hr (perindoprilat): Peak plasma time: 1 hr (PO; perindopril); 3-7 hr (perindoprilat), Therapeutic concentration range: 80-150 ng/mL, Renal clearance: 1.5 L/h (perindopril), 6-10 L/hr (perindoprilat total body: 21-31 L/h perindopril): 46 L/hr) (perindoprilat), Bioavailability: 75% (perindopril); 20-30% (perindoprilat), Protein bound: 60% (perindopril); 10-20% (perindoprilat), Vd: 0.22 L/kg (perindopril); 0.16 L/kg (perindoprilat), Metabolites: Perindoprilat (active), glucuronide derivatives (inactive). Use Caution/Monitor. Serious - Use Alternative (1)verapamil will increase the level or effect of infigratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)caspofungin will increase the level or effect of valsartan by Other (see comment). Trimethoprim decreases urinary potassium excretion. Hardcopies of approved proposals Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Coadministration may result in a significant decrease in renal function. Monitor Closely (1)hydralazine will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by unspecified interaction mechanism. Observe for possible additive hypotensive effects during concomitant use. perindopril, pregabalin. Monitor Closely (2)verapamil will increase the level or effect of deflazacort by P-glycoprotein (MDR1) efflux transporter. Shay K, et al. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. Minor (1)shepherd's purse, valsartan. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Use Caution/Monitor. pharmacodynamic antagonism. Monitor Closely (2)verapamil will increase the level or effect of aliskiren by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Therapy with carbidopa, given with or without levodopa or carbidopa-levodopa combination products, is started, dosage adjustment of the antihypertensive drug may be required. Knowledge about dosage, active ingredients, value, and brand reputation may help guide your decision. Use Caution/Monitor. ALA is important for the citric acid cycle, which is the series of chemical reactions that produce adenosine triphosphate (ATP), the primary energy currency of our body. hydralazine increases effects of pindolol by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Monitor Closely (1)verapamil will increase the level or effect of prednisolone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Am J Clin Nutr. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug.verapamil will increase the level or effect of erythromycin lactobionate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)verapamil will increase the level or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of anaphylaxis, Stevens Johnson syndrome. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Monitor Closely (1)sofosbuvir/velpatasvir increases levels of valsartan by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Minor (1)verapamil will increase the level or effect of cevimeline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. Either increases toxicity of the other by Other (see comment). Either increases toxicity of the other by Other (see comment). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Use Caution/Monitor. nefazodone will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Enhanced antiplatelet activity. Either increases effects of the other by pharmacodynamic synergism. Looking at studies conducted over the previous 13 years, the report's authors determined that oat-derived beta-glucan may significantly reduce levels of total and low-density lipoprotein (LDL) or "bad" cholesterol. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Avoid coadministration of pazopanib with strong CYP3A4 inhibitors if possible; if must coadminister, decrease pazopanib dose to 400 mg/day. verapamil will increase the level or effect of irinotecan liposomal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. valsartan and carvedilol both increase serum potassium. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Risk of neutropenia. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.valsartan, mefenamic acid. Mechanism: pharmacodynamic synergism. Monitor Closely (1)valsartan and potassium chloride both increase serum potassium. commonly, these are "non-preferred" brand drugs. Minor/Significance Unknown. calcium acetate decreases effects of verapamil by pharmacodynamic antagonism. Monitor Closely (1)verapamil will increase the level or effect of lumateperone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the level or effect of verapamil by altering metabolism. Monitor glycemic control especially during the first month of treatment with an ACE inhibitor. verapamil increases levels of amoxapine by decreasing metabolism. Minor (1)verapamil will increase the level or effect of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)hydralazine will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)carbidopa increases effects of perindopril by pharmacodynamic synergism. NSAIDs decrease prostaglandin synthesis. pharmacodynamic antagonism. Serious - Use Alternative (1)sotorasib will decrease the level or effect of verapamil by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. A systematic review and meta-analysis of randomized controlled trials of the effect of barley -glucan on LDL-C, non-HDL-C and apoB for cardiovascular disease risk reductioni-iv[published correction appears in Eur J Clin Nutr. Avoid or Use Alternate Drug. Mechanism: pharmacodynamic synergism. Modify Therapy/Monitor Closely. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis. Minor (1)creatine, perindopril. Monitor Closely (1)isoniazid will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. valsartan increases and methyclothiazide decreases serum potassium. valsartan and atenolol both increase serum potassium. Use Caution/Monitor.verapamil will increase the level or effect of dexamethasone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Monitor Closely (1)verapamil will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor CYP3A substrates if coadministered. Monitor Closely (1)verapamil, cyclosporine. sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of valsartan by Other (see comment). Serious - Use Alternative (1)abametapir will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. The results from an in vitro study with human liver tissue indicate that valsartan is a substrate of the hepatic uptake transporter OATP1B1; coadministration with OATP1B1 inhibitors may increase valsartan systemic exposure. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)perindopril, azathioprine. Use Caution/Monitor. Use Caution/Monitor. restrictions. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. View the formulary and any restrictions for each plan. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. Modify Therapy/Monitor Closely. Caution should be exercised with concomitant use of moderate CYP3A4 inhibitors. Heart Failure (Off-label) Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine. Minor (1)verapamil increases effects of rocuronium by pharmacodynamic synergism. Minor (1)shepherd's purse, hydralazine. Modify Therapy/Monitor Closely. Bashir KMI, Choi JS. Fostemsavir inhibits OATP1B1/3 transporter. Mushrooms treated with UV lamps can produce even higher amounts of vitamin D. Either increases effects of the other by pharmacodynamic synergism. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Monitor Closely (3)valsartan, oxaprozin. Use Caution/Monitor. Avoid coadministration of sonidegib with moderate CYP3A4 inhibitors. TCA level may be increased.Minor (1)verapamil increases levels of imipramine by decreasing metabolism. Use Caution/Monitor.Serious - Use Alternative (2)verapamil increases levels of bosutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)mitotane decreases levels of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use Caution/Monitor. Use Caution/Monitor. Information suggests voclosporin (an OATP1B1 inhibitor) may increase in the concentration of OATP1B1 substrates is possible. Use Caution/Monitor. Use Caution/Monitor. On my first bottle so a bit early to be sure but they do see to be helping with focus and energy. Monitor patients for changes in glycemic control. Exaggerated first dose hypotensive response. Minor/Significance Unknown. Monitor Closely (1)acebutolol and verapamil both increase anti-hypertensive channel blocking. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Use Caution/Monitor. Verapamil also inhibits P-gp activity, which can further increase rivaroxaban serum levels; since both pathways of rivaroxaban elimination are affected, patients with renal impairment receiving rivaroxaban with drugs that are combined P-gp and moderate CYP3A4 inhibitors may increase exposure compared to patients with normal renal function; monitor for bleeding. If coadministration with strong or moderate CYP3A4 inhibitors is unavoidable, reduce pemigatinib dose (refer to drug monograph dosage modifications). Use Caution/Monitor. Monitor Closely (2)eslicarbazepine acetate will decrease the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Minor (1)cornsilk increases effects of hydralazine by pharmacodynamic synergism. Monitor Closely (1)verapamil, sodium sulfate/potassium sulfate/magnesium sulfate. perindopril, asenapine. Use Caution/Monitor. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. Effect of interaction is not clear, use caution. Either increases toxicity of the other by Other (see comment). Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Coadministration may result in a significant decrease in renal function. verapamil will increase the level or effect of deflazacort by affecting hepatic/intestinal enzyme CYP3A4 metabolism. valsartan and sulindac both increase serum potassium. Enhanced antiplatelet activity. trimethoprim will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. Monitor Closely (1)verapamil increases levels of green tea by decreasing elimination. Monitor Closely (1)hydralazine, dopamine. Modify Therapy/Monitor Closely. Use Caution/Monitor. Comment: ACE inhibitors may increase hypoglycemic effect. verapamil will increase the level or effect of dihydroergotamine intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Use Caution/Monitor. Modify Therapy/Monitor Closely. Sympathomimetics can antagonize the activity of some antihypertensive agents.hydralazine, serdexmethylphenidate/dexmethylphenidate. Use Caution/Monitor. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the P-gp substrate and titrate to clinical effect.Serious - Use Alternative (1)verapamil increases levels of eliglustat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor heart rate in patients receiving concomitant verapamil and clonidine. Monitor Closely (1)maitake increases effects of valsartan by pharmacodynamic synergism. Use Caution/Monitor. Contraindicated. verapamil will increase the level or effect of zanubrutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. Use Caution/Monitor. Both drugs decrease blood glucose. Risk of hypotension. Minor/Significance Unknown. Monitor Closely (1)verapamil increases levels of nintedanib by P-glycoprotein (MDR1) efflux transporter. Comment: Potential for increased risk of hypotension with concurrent use. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)labetalol and verapamil both increase anti-hypertensive channel blocking. hydrochlorothiazide will increase the level or effect of verapamil by basic (cationic) drug competition for renal tubular clearance. Risk of fetal compromise if given during pregnancy. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: aliskiren, lithium, drugs that may increase the level of potassium in the blood (such as ACE inhibitors including benazepril/lisinopril, birth control pills containing drospirenone).Some products have ingredients that could raise your blood pressure or worsen your heart failure. verapamil will increase the level or effect of fludrocortisone by P-glycoprotein (MDR1) efflux transporter. Consult your doctor for more details.Lab and/or medical tests (such as kidney function tests, potassium levels) should be done while you are taking this medication. Use Caution/Monitor.Serious - Use Alternative (1)saquinavir will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)nabumetone, perindopril. Risk of hypertension. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)verapamil increases levels of ethanol by decreasing metabolism. bosutinib increases levels of verapamil by P-glycoprotein (MDR1) efflux transporter. When shopping for supplements, look for brands tested by a trusted, independent third party, such as U.S. Pharmacopeia, NSF International, or ConsumerLab. If you are planning pregnancy, become pregnant, or think you may be pregnant, tell your doctor right away. Minor (1)shepherd's purse, perindopril. verapamil will increase the level or effect of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dual blockade of renin-angiotensin system increases risks of hypotension, hyperkalemia, and renal impairment. glyburide will increase the level or effect of valsartan by Other (see comment). HOW TO USE: Take this medication by mouth with or without food as directed by your doctor, usually once daily. verapamil will increase the level or effect of vincristine liposomal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (2)atazanavir will increase the level or effect of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Additive hypotensive effects.carvedilol increases effects of hydralazine by pharmacodynamic synergism. Risk of hypertension. Coadministration may result in a significant decrease in renal function. 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